Academician Zhang Gaiping's team from the Chinese Academy of Engineering published a research paper titled 'Rice-produced classical swine fever virus glycoprotein E2 with herringbone-dimer design to enhance immune responses' in the authoritative journal Plant Biotechnology Journal. The research paper, using rice endosperm to express the classical swine fever virus E2, describes a simple and efficient vaccine design strategy. By expressing the 'herringbone' E2 dimer (ht-rE2 dimer) in rice, the study elucidates the potential of the rice expression system to precisely express designed proteins in vitro. The expressed E2 dimer possesses the natural conformation of viral envelope proteins and efficient antigenicity, while also being safe, easy to produce on a large scale, and cost-effective. This research provides a theoretical basis for the molecular design of animal vaccines produced in rice.
Dr. Xu Qianru and Dr. Ma Fanshu are the co-first authors of this paper. Dr. Zhang Gaiping, Academician from our School of Animal Medicine, and Associate Professor Zhang Erqin from the School of Animal Medicine are the co-corresponding authors of this paper.
